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Recombinant basic fibroblast growth factor inhibits the airway hyperresponsiveness, mucus production, and lung inflammation induced by an allergen challenge 

Published byJosé Miguel Macías Modified over 5 years ago

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Presentation on theme: "Recombinant basic fibroblast growth factor inhibits the airway hyperresponsiveness, mucus production, and lung inflammation induced by an allergen challenge "— Presentation transcript:

1 Recombinant basic fibroblast growth factor inhibits the airway hyperresponsiveness, mucus production, and lung inflammation induced by an allergen challenge  Seong Gyu Jeon, BSc, Chun Geun Lee, MD, Min-Hee Oh, BSc, Eun-Young Chun, BSc, Yong Song Gho, PhD, Sang-Heon Cho, MD, Jong-Hoon Kim, PhD, Kyung-Up Min, MD, You-Young Kim, MD, Yoon-Keun Kim, MD, Jack A. Elias, MD  Journal of Allergy and Clinical Immunology  Volume 119, Issue 4, Pages (April 2007) DOI: /j.jaci Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 AHR kinetics in lung-specific TGF-β1 TG (+) and FGF2-deficient mice after administering water containing doxycycline. A and C show a representative experiment out of 5 replicates. A, Methacholine AHR was lower in TGF-β1 (+) mice than in littermate WT controls 7 and 14 days after dox administration. ∗P < .05 compared with WT. B, Enhanced FGF2 mRNA expression in the TGF-β1 TG (+) lungs of different lines (Lines 20 and 36). C, Enhanced methacholine AHR in TGF-β1 (+) mice with homozygous disruption of the FGF2 gene 14 days after dox administration. ∗P < .05 compared with TGF-1 (+)/FGF2+/+; ∗∗P < .05 compared with the other groups. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Study protocol and determination of an optimal dose of rFGF2. A, Study protocol. B, BAL cellularity in asthma mice treated with different doses of rFGF2 (n = 5 each group): BAL cellularity was significantly decreased in asthma mice treated with 10 or 20 μg of rFGF2, but not with 1 μg of rFGF2, than in asthma mice treated with sham. ∗P < .05. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Therapeutic effects of recombinant FGF2 (10 μg) in an asthma mouse model (n = 5 each group). ∗P < .05 compared with the other groups. A, Methacholine AHR. B, BAL cellularity. C, Lung histology. (A and C: OVA-challenged mice without FGF2 treatment; B and D: OVA-challenged mice treated with FGF2; A and B: Hematoxylin and eosin stain; C and D: DPAS stain, ×200.) D, Inflammatory scores. E, Grades of mucus staining cells. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Immunomodulating effects of recombinant FGF2 in an asthma mouse model. A and B show a representative experiment out of 5 replicates. A, BAL cytokine levels: rFGF2 treatment significantly inhibited BAL IL-13 and VEGF production after OVA challenge. ∗P < .05 compared with the other groups. B, Proliferation assay of T cells derived from regional L/N. For OVA-challenged mice, OVA-induced T-cell proliferation was significantly inhibited in mice treated with rFGF2 compared with untreated mice. ∗P < .05 compared with PBS-challenged mice; ∗∗P < .05 compared with the other groups. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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