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Getting to the Core of Repeat Expansions by Cell Reprogramming

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Presentation on theme: "Getting to the Core of Repeat Expansions by Cell Reprogramming"— Presentation transcript:

1 Getting to the Core of Repeat Expansions by Cell Reprogramming
Sergei M. Mirkin  Cell Stem Cell  Volume 7, Issue 5, Pages (November 2010) DOI: /j.stem Copyright © 2010 Elsevier Inc. Terms and Conditions

2 Figure 1 Hypothetical Molecular Mechanisms Leading to Repeat Expansions upon Cell Reprogramming Fibroblasts from Friedreich's ataxia patients harbor unstable, (GAA)n repeats (red bar) that can be expanded via a variety of potential mechanisms during transcription factor-mediated reprogramming. MMR, mismatch repair; TCR, transcription-coupled repair. Cell Stem Cell 2010 7, DOI: ( /j.stem ) Copyright © 2010 Elsevier Inc. Terms and Conditions


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