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Heterozygous Pik3caH1047R oncogenic mutation causes invasive prostate cancer in mice that does not phenocopy Pten deletion. Heterozygous Pik3caH1047R oncogenic.

Published byLeony Pranata Modified over 5 years ago

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Presentation on theme: "Heterozygous Pik3caH1047R oncogenic mutation causes invasive prostate cancer in mice that does not phenocopy Pten deletion. Heterozygous Pik3caH1047R oncogenic."— Presentation transcript:

1 Heterozygous Pik3caH1047R oncogenic mutation causes invasive prostate cancer in mice that does not phenocopy Pten deletion. Heterozygous Pik3caH1047R oncogenic mutation causes invasive prostate cancer in mice that does not phenocopy Pten deletion. A, Representative hematoxylin/eosin images of WT, Pik3ca+/HR, and Ptenfl/fl dorsolateral prostate epithelium (scale bar, 100 μm). B, Histogram displaying phenotype incidence in WT, Pik3ca+/HR, and Ptenfl/fl dorsolateral prostate. DLP, dorsolateral prostate. C, Bar graph displaying total prostate weight normalized to body weight for WT, Pik3ca+/HR, and Ptenfl/fl mice. n = as indicated (N). Error bars, SEM, *, P < 0.05 compared with WT, one-way ANOVA with Tukey multiple comparison test. Helen B. Pearson et al. Cancer Discov 2018;8: ©2018 by American Association for Cancer Research

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