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Heterogeneity of severe asthma in childhood: Confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and.

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Presentation on theme: "Heterogeneity of severe asthma in childhood: Confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and."— Presentation transcript:

1 Heterogeneity of severe asthma in childhood: Confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program  Anne M. Fitzpatrick, PhD, W. Gerald Teague, MD, Deborah A. Meyers, PhD, Stephen P. Peters, MD, PhD, Xingnan Li, PhD, Huashi Li, MS, Sally E. Wenzel, MD, Shean Aujla, MD, Mario Castro, MD, Leonard B. Bacharier, MD, Benjamin M. Gaston, MD, Eugene R. Bleecker, MD, Wendy C. Moore, MD  Journal of Allergy and Clinical Immunology  Volume 127, Issue 2, Pages e13 (February 2011) DOI: /j.jaci Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 A, Frequency of children with mild, moderate, and severe asthma defined by NAEPP or GINA guidelines. B, Frequency of children with mild-to-moderate and severe asthma defined by ATS criteria in each cluster (cluster 1, black bars; cluster 2, white bars; cluster 3, gray bars; cluster 4, hatched bars). Journal of Allergy and Clinical Immunology  , e13DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Scatterplot of the discriminant functions generated from discriminant analysis of asthma duration, the extent of asthma controller therapy, and baseline FEV1 percent predicted values. Each data point represents a single subject. The plot depicts clustering and separation of cluster 1 (white triangles), cluster 2 (gray circles), cluster 3 (black squares), and cluster 4 (white diamonds) using these 3 variables. Journal of Allergy and Clinical Immunology  , e13DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Dendogram. Using the Wald minimum-variance hierarchical clustering method and an agglomerative (bottom-up approach), 161 subjects from the NIH/NHLBI SARP were clustered into a single final group. At each generation of clusters, samples were merged into larger clusters to minimize the within-cluster sum of squares or maximize the between-subjects sum of squares. With successive clustering, 4 groups were apparent. Journal of Allergy and Clinical Immunology  , e13DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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