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AMPK and p53 help cells through lean times

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Presentation on theme: "AMPK and p53 help cells through lean times"— Presentation transcript:

1 AMPK and p53 help cells through lean times
Carson C. Thoreen, David M. Sabatini  Cell Metabolism  Volume 1, Issue 5, Pages (May 2005) DOI: /j.cmet Copyright © 2005 Elsevier Inc. Terms and Conditions

2 Figure 1 AMPK is activated by many forms of metabolic stress, including glucose starvation AMPK can then induce a cell-cycle arrest by phosphorylating and stabilizing p53, a transcription factor that is also activated by ionizing radiation, UV light, and abberant growth-factor signaling. Cell Metabolism 2005 1, DOI: ( /j.cmet ) Copyright © 2005 Elsevier Inc. Terms and Conditions

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