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Reduced Late Mortality Risk Contributes to Similar Survival after Double-Unit Cord Blood Transplantation Compared with Related and Unrelated Donor Hematopoietic.

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Presentation on theme: "Reduced Late Mortality Risk Contributes to Similar Survival after Double-Unit Cord Blood Transplantation Compared with Related and Unrelated Donor Hematopoietic."— Presentation transcript:

1 Reduced Late Mortality Risk Contributes to Similar Survival after Double-Unit Cord Blood Transplantation Compared with Related and Unrelated Donor Hematopoietic Stem Cell Transplantation  Doris M. Ponce, Junting Zheng, Anne Marie Gonzales, Marissa Lubin, Glenn Heller, Hugo Castro-Malaspina, Sergio Giralt, Katharine Hsu, Ann A. Jakubowski, Robert R. Jenq, Guenther Koehne, Esperanza B. Papadopoulos, Miguel A. Perales, Marcel R. van den Brink, James W. Young, Farid Boulad, Nancy A. Kernan, Rachel Kobos, Susan Prockop, Andromachi Scaradavou, Trudy Small, Richard J. O’Reilly, Juliet N. Barker  Biology of Blood and Marrow Transplantation  Volume 17, Issue 9, Pages (September 2011) DOI: /j.bbmt Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 The cumulative incidence of TRM after CB-T, RD-T, and URD-T: increased early mortality after CB-T was compensated for by reduced late mortality such that the 2-year TRM after CB-T was not different from that of RD-T and URD-T recipients. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 The Kaplan-Meier incidence of OS after CB-T, RD-T, and URD-T: OS after CB-T was similar when compared with RD-T and URD-T. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 The Kaplan-Meier incidence of PFS after CB-T, RD-T, and URD-T: 2 year PFS after CB-T was not different from that of RD-T and URD-T recipients. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

5 Figure 4 Comparison of causes of death in the 2-year posttransplant according to HSC source: relapse followed by organ failure was the most frequent primary cause of death in RD-T and CB-T recipients, whereas relapse and GVHD were the most frequent primary causes of death in URD-T recipients. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

6 Figure 5 Comparison of relapse after CB-T, RD-T, and URD-T in patients with acute leukemia transplanted in remission: CB-T recipients had a low risk of relapse. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions


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