1. Treatment of a giant squamous cell carcinoma on the dominant thumb with intralesional 5-fluorouracil 
Diane M. Reisinger, MD, Armand B. Cognetta, MD, L. Terry Pynes, MD, Alfredo A. Paredes, MD, Timothy J. Sweeney, MD, David J. Dolson, MD 
Journal of the American Academy of Dermatology 
Volume 65, Issue 1, Pages (July 2011)
DOI: /j.jaad
Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions

2. Fig 1
A, Squamous cell carcinoma on the right mid dorsal surface of the thumb before treatment with intralesional 5-fluorouracil. B, Pretreatment biopsy specimen of well differentiated squamous cell carcinoma. C, Magnetic resonance imaging scan of the thumb. Top, Contrasted T1 image shows an ulcerating lesion arising on the dorsal surface of the thumb penetrating full depth through subcutaneous fat and in apposition to the extensor tendon sheath (tip of arrows). Bottom, Adjacent slice shows lesion appears to surround extensor tendon and may involve tendon sheath (tip of arrows). (B, Hematoxylin–eosin stain; original magnifications: Top, ×20; bottom, ×40.)
Journal of the American Academy of Dermatology  , DOI: ( /j.jaad )
Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions

3. Fig 2
A, Weekly intralesional injections of 100 mg of 5-fluorouracil into nine quadrants. B, Two weeks following the sixth (and final) intralesional 5-fluorouracil injection with complete clinical resolution of the squamous cell carcinoma. C, Representative posttreatment biopsy specimen showing histologic resolution of the squamous cell carcinoma. (C, Hematoxylin–eosin stain; original magnification: ×20.)
Journal of the American Academy of Dermatology  , DOI: ( /j.jaad )
Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions