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Targetoid hemosiderotic hemangiomas (hobnail hemangiomas) are vascular lymphatic malformations: A study of 12 pediatric cases  Rola Al Dhaybi, MD, Christina.

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Presentation on theme: "Targetoid hemosiderotic hemangiomas (hobnail hemangiomas) are vascular lymphatic malformations: A study of 12 pediatric cases  Rola Al Dhaybi, MD, Christina."— Presentation transcript:

1 Targetoid hemosiderotic hemangiomas (hobnail hemangiomas) are vascular lymphatic malformations: A study of 12 pediatric cases  Rola Al Dhaybi, MD, Christina Lam, MD, Afshin Hatami, MD, FRCPC, Julie Powell, MD, FRCPC, Catherine McCuaig, MD, FRCPC, Victor Kokta, MD, FRCPC  Journal of the American Academy of Dermatology  Volume 66, Issue 1, Pages (January 2012) DOI: /j.jaad Copyright © 2011 American Academy of Dermatology, Inc. Terms and Conditions

2 Fig 1 A, Multiple ectatic blood vessels with hobnail endothelial cells in papillary dermis and slitlike blood vessels within reticular dermis. B, Dermal collapsed angulated vascular channels dissecting through collagen bundles with numerous adjacent siderophages (arrow). (A and B, Hematoxylin-phloxine-saffron stain; original magnifications: A, ×200; B, ×400.) Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2011 American Academy of Dermatology, Inc. Terms and Conditions

3 Fig 2 Patch of 3 cm in diameter composed of two components: telangiectasia overlying brown to violaceous ecchymotic lesion, and light brown ecchymotic lesion. Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2011 American Academy of Dermatology, Inc. Terms and Conditions

4 Fig 3 A, Positive staining of hobnail endothelial cells in ectatic dermal vessels for lymphatic marker podoplanin using D2-40 antibody. B, Negative staining with Wilms tumor-1 gene (WT-1) within ectatic dermal vessels of targetoid hemosiderotic hemangioma (THH). C, Very low Ki-67 proliferation index (<2%) within ectatic dermal vessels of THH (A, D2-40; B, WT-1; and C, Ki-67 stains; original magnifications: ×200.) Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2011 American Academy of Dermatology, Inc. Terms and Conditions


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