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Fig. 3 Superiority of BAFF-R versus CD19-CAR T cells in a Burkitt lymphoma model is not due to greater tumor antigen density. Superiority of BAFF-R versus.

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Presentation on theme: "Fig. 3 Superiority of BAFF-R versus CD19-CAR T cells in a Burkitt lymphoma model is not due to greater tumor antigen density. Superiority of BAFF-R versus."— Presentation transcript:

1 Fig. 3 Superiority of BAFF-R versus CD19-CAR T cells in a Burkitt lymphoma model is not due to greater tumor antigen density. Superiority of BAFF-R versus CD19-CAR T cells in a Burkitt lymphoma model is not due to greater tumor antigen density. (A) Bioluminescence images of groups of five NSG mice after intravenous tumor challenge (0.5 × 106 cells per mouse) on day 0 with luciferase-expressing Raji cells. Activated CD4 TN CAR T (2.5 × 106) CD8 TN BAFF-R– or CD19-CAR T cells were infused intravenously on day 7 as a single dose. Control mice received nontransduced CD4/CD8 T cells from the same donor as an allogeneic control, or PBS. Data are representative of two independent experiments using different donor T cells. (B) Kaplan-Meier plot of overall survival at 80 days is shown. Log-rank test: **P < 0.01 compared with all other groups. (C) Calculated cell surface antigen density of BAFF-R and CD19 on lymphoma and leukemia lines stained by PE-conjugated antibodies at saturation. PE per cell (assuming one PE per antibody) was calculated against mean fluorescence intensity standard curve with BD Quantibrite beads. Data are represented as means ± SD of triplicates. Student’s t test: **P < BAFF-R versus CD19 in corresponding cell line. Hong Qin et al., Sci Transl Med 2019;11:eaaw9414 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works

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