1. (Left) Observed (symbols) and predicted (lines) response (bacterial count, CFU) vs. time after administration of 1.5, 2, 4, and 6 µg of a new antibiotic.
(Left) Observed (symbols) and predicted (lines) response (bacterial count, CFU) vs. time after administration of 1.5, 2, 4, and 6 µg of a new antibiotic. Note the large range of counts (more than three orders of magnitude). (Right) First-order bacterial growth coupled to the second-order bacterial kill model. The first-order growth kg ⋅ N ⋅ (1 − N/Nmax) is saturable by means of the (1 − N/Nmax) term, where kg, N, and Nmax denote the first-order growth rate constant, the number of bacteria, and the maximum bacterial count, respectively. The bacterial kill process is approximated by –kkf(Ab) ⋅ N, where kk, N, and Ab denote the first-order kill rate constant, the number of bacteria, and the plasma concentration of drug. CFU, colony-forming unit.
Johan Gabrielsson et al. Pharmacol Rev 2019;71:89-122
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