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Lipotoxicity, β Cell Dysfunction, and Gestational Diabetes

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Presentation on theme: "Lipotoxicity, β Cell Dysfunction, and Gestational Diabetes"— Presentation transcript:

1 Lipotoxicity, β Cell Dysfunction, and Gestational Diabetes
Christopher J. Nolan  Cell Metabolism  Volume 19, Issue 4, Pages (April 2014) DOI: /j.cmet Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 Chemical Structure of a Furan Fatty Acid and Its Metabolism to the Bibasic Urofuran CMPF Furan fatty acids have a furan ring substituted with a saturated fatty acid in one α position and either a propyl or a pentyl alkyl group in the other α position. Either both β positions are substituted with methyl groups, or only the β position adjacent to the fatty acid chain has a methyl group. Catabolism to bibasic urofurans involves the degradation of the α position long chain fatty acid to propianoic acid and the conversion of the adjacent methyl group to carboxylic acid. Shown here is a furan fatty acid with a methyl group in both β positions and a propyl alkyl group that is catabolized into CMPF. Cell Metabolism  , DOI: ( /j.cmet ) Copyright © 2014 Elsevier Inc. Terms and Conditions

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