1. Schematic depiction of three stages of the natural history of T2D, noting several opportunities for improvement of management.
Schematic depiction of three stages of the natural history of T2D, noting several opportunities for improvement of management. During the period before diagnosis, risk factors for developing diabetes call for systematic screening to reduce the interval between onset and diagnosis, thereby reducing an untreated interval of hyperglycemia. At diagnosis, specific subtypes of diabetes may be identified. During the early stages of T2D, evidence-based standard treatment algorithms may be effective in controlling glucose and reducing later complications. At some point in each individual’s experience, often close to 10 years after diagnosis, more individualized therapy is likely to be needed, including consideration of newer therapeutic agents with nonglycemic effects that reduce the risk of CV events. GDM, gestational diabetes mellitus; IFG, impaired fasting glucose; IGT, impaired glucose tolerance; LADA, latent autoimmune diabetes in adults.
Bernard Zinman et al. Dia Care 2017;40:
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