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Frequency of CD4+CD25+FoxP3+, CD4+CD25+CD127low, and CD4+CD25+LAP+ T cells before and after treatment with anti–CTLA-4. Frequency of CD4+CD25+FoxP3+, CD4+CD25+CD127low,

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Presentation on theme: "Frequency of CD4+CD25+FoxP3+, CD4+CD25+CD127low, and CD4+CD25+LAP+ T cells before and after treatment with anti–CTLA-4. Frequency of CD4+CD25+FoxP3+, CD4+CD25+CD127low,"— Presentation transcript:

1 Frequency of CD4+CD25+FoxP3+, CD4+CD25+CD127low, and CD4+CD25+LAP+ T cells before and after treatment with anti–CTLA-4. Frequency of CD4+CD25+FoxP3+, CD4+CD25+CD127low, and CD4+CD25+LAP+ T cells before and after treatment with anti–CTLA-4. Representative patient who had an increase in frequency of CD4+CD25+FoxP3+ and CD4+CD25+CD127low T cells but not in CD4+CD25+LAP+ T cells after treatment with anti–CTLA-4 (posttherapy) as compared with before treatment (pretherapy) (A). Summary data from 3 patients who had an increase in frequency of CD4+CD25+FoxP3+ and CD4+CD25+CD127low T cells but not in CD4+CD25+LAP+ T cells after treatment with anti–CTLA-4 (Post) as compared with before treatment (Pre) (B). Representative patient who had an increase in frequency of CD4+CD25+FoxP3+, CD4+CD25+CD127low, and CD4+CD25+LAP+ T cells after treatment with anti–CTLA-4 (posttherapy) as compared with before treatment (pretherapy) (C). Summary data from 3 patients who had an increase in frequency of CD4+CD25+FoxP3+, CD4+CD25+CD127low, and CD4+CD25+LAP+ T cells after treatment with anti–CTLA-4 (Post) as compared with before treatment (Pre) (D). Representative thymidine incorporation assay, which measured cell proliferation in the presence of media only, CD4+CD25+LAP+ T cells only with a ratio of R:S of 0:1, CD4+CD25+CD127low cells only with a R:S ratio of 0:1, responder CD4+CD252 cells only with a ratio of R:S of 1:0, a mixture of R:S (CD4+CD25+CD127low) at a ratio of 1:1, and a mixture of R:S (CD4+CD25+LAP+ cells) at a ratio of 1:1 (E). Each experiment was performed in triplicate and suppression assays were repeated with 3 different donor samples. Bars represent mean ± SEM. Jingjing Sun et al. Cancer Discovery 2012;2: ©2012 by American Association for Cancer Research

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