1. STK11/LKB1 comutations are associated with inferior objective response rate with PD-1 blockade in KRAS-mutant LUAC. A, Objective response rate (RECISTv1.1) to PD-1 axis blockade in the KL, KP, and K-only subgroups in the overall SU2C population (N = 173 res...
STK11/LKB1 comutations are associated with inferior objective response rate with PD-1 blockade in KRAS-mutant LUAC. A, Objective response rate (RECISTv1.1) to PD-1 axis blockade in the KL, KP, and K-only subgroups in the overall SU2C population (N = 173 response-evaluable patients) and in each of the three independent cohorts (MDACC, MSKCC, DFCI/MGH). A two-tailed Fisher exact test (computed from a 2 × 3 contingency table) was used to assess the significance of the association between group membership and best overall response (BOR; PR/CR vs. SD/PD). B, Objective response rate to nivolumab in the KL, KP, and K-only subgroups in the CheckMate-057 international randomized phase III clinical trial (n = 24). A two-tailed Fisher exact test (computed from a 2 × 3 contingency table) was used to assess the significance of the association between group membership and best overall response (PR/CR vs. SD/PD). PR, partial response; CR, complete response; SD, stable disease; PD, progressive disease. C, Waterfall plots illustrating individual patient-level maximal % change in tumor burden from baseline in response to PD-1/PD-L1 inhibition in the SU2C cohort. Only data from response-evaluable patients with measurable disease are graphed. Red, progressive disease; purple, stable disease; blue, partial response/complete response.
Ferdinandos Skoulidis et al. Cancer Discov 2018;8:
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