1. Overcoming ATM Deficiency by Activating the NAD+/SIRT1 Axis
Leonard Guarente 
Cell Metabolism 
Volume 24, Issue 4, Pages (October 2016)
DOI: /j.cmet
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1 Suppression of ATM−/− Phenotypes by NR
ATM depletion results in inactivation of the Mre11-Rad50-Nbs1 (MRN) complex, Ku70, and DNA protein kinase (DNAPK), thereby causing persistent DNA damage, PARP activation, and NAD+ consumption. The resulting NAD+ deficiency then leads to SIRT1 inactivation, a defect in mitophagy, and mitochondrial dysfunction. NR restores mitochondrial function by reactivating SIRT1 and rescues DNA damage by activating Ku70 and DNAPK via SIRT1 and SIRT6. As a result, improved mitochondrial health and longer lifespan are provided to ATM−/− mice by NR.
Cell Metabolism  , DOI: ( /j.cmet )
Copyright © 2016 Elsevier Inc. Terms and Conditions