1. Beginning of the chapter Epigenetics and genetics18
Beginning of the chapter
Epigenetics and genetics

2. GENETICS
Epi-Genetics

3. Genetics - blueprint of the body
EPIGENETICS
What is epigenetics?
Genetics - blueprint of the body
Instruction: How is food digested?
Instruction: How are blood sugar levels regulated?
Instruction: What color should eyes have?
Instruction: How are strong bones built?
Gene defective >> missing function of the body >> disease
Epigenetics - "volume control" for the genes
Environmental factors turn genes on (make them LOUDER)
Environmental factors turn genes off (they make QUIETER)
„Louder“ und „Quieter“ genes influence processes in the body
Epigenetic programming can be inherited

4. EPIGENETICS What is epigenetics? 1944 Netherlands 1947 Netherlands
1997
Netherlands
2013
Netherlands
Famine
400kcal/Day
Heart disease
Breast cancer
Obesity
Heart disease
Breast cancer
Obesity
Environmental impact on the mother in 1944 influences the health of the descendants two generations later

5. How does epigenetics work?
Lactose digestion
Lactose digestion
GTCTTACTTAGCCCTTTAAAGATCGAATCCGCGGCAGAATACATCGAAGGATTCGCTATATTAGG
Heterochromatin

6. How does epigenetics work?
Famine
400kcal/Tag
Function A
Function B
Function C
Function D
Function E
Function F

7. How does epigenetics work?

8. How does epigenetics work?
If epigenetics can turn on or off different genes, doesn‘t this overrule the genetic defects?
Lactose digestion
GTCTTACTTAGCCCTTTAAAGATCGAATCCGCGGCAGAATACATCGAAGGATTCGCTATATTAGG
Answer:
Some genetic defects destroy the instructions for the body. These instructions are completely lost, and cannot be recovered by epigenetics.
>> Gene mutations cause severe diseases

9. Epigenetics and genetics18
End of the chapter
Epigenetics and genetics