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Antithrombin levels during pediatric cardiopulmonary bypass: Key to changing a decades-old paradigm for anticoagulation?  Dean B. Andropoulos, MD, MHCM,

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Presentation on theme: "Antithrombin levels during pediatric cardiopulmonary bypass: Key to changing a decades-old paradigm for anticoagulation?  Dean B. Andropoulos, MD, MHCM,"— Presentation transcript:

1 Antithrombin levels during pediatric cardiopulmonary bypass: Key to changing a decades-old paradigm for anticoagulation?  Dean B. Andropoulos, MD, MHCM, Charles D. Fraser, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 151, Issue 2, Pages (February 2016) DOI: /j.jtcvs Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Binding of antithrombin (AT), thrombin (T), and heparin (H).
(Reproduced with permission of Nature Publishing Group from Li W, Johnson DJ, Esmon CT, Huntington JA. Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin. Nat Struct Mol Biol. 2004;11: ) The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

3 Thrombin-antithrombin-heparin binding.
The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions


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