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Antithrombin levels during pediatric cardiopulmonary bypass: Key to changing a decades-old paradigm for anticoagulation? Dean B. Andropoulos, MD, MHCM, Charles D. Fraser, MD The Journal of Thoracic and Cardiovascular Surgery Volume 151, Issue 2, Pages (February 2016) DOI: /j.jtcvs Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions
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Figure 1 Binding of antithrombin (AT), thrombin (T), and heparin (H).
(Reproduced with permission of Nature Publishing Group from Li W, Johnson DJ, Esmon CT, Huntington JA. Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin. Nat Struct Mol Biol. 2004;11: ) The Journal of Thoracic and Cardiovascular Surgery , DOI: ( /j.jtcvs ) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions
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Thrombin-antithrombin-heparin binding.
The Journal of Thoracic and Cardiovascular Surgery , DOI: ( /j.jtcvs ) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions
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