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Understanding the Basics of Dementia-Related Psychosis

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Presentation on theme: "Understanding the Basics of Dementia-Related Psychosis"— Presentation transcript:

1 Understanding the Basics of Dementia-Related Psychosis

2 Dementia

3 Etiological Subtype of Major and Mild NCDs

4 Dementia-Related Psychosis

5 Prevalence of Dementia and DRP in the USA

6 Diagnosis of DRP

7 Excluding Non-Dementia-Related Causes for Psychotic Symptoms

8 Measuring the Type, Frequency, Severity, Pattern, and Timing of Psychosis Symptoms in Clinical Practice

9 Neurobiology of NPS in Patients With Dementia

10 Neurobiology of NPS in Patients With Dementia (cont)

11 Potential Role of Genetics in DRP

12 Burden of DRP on Caregiver

13 AA Recommendations for the Nonpharmacologic Approach to BPSD

14 Rationale for Antipsychotic Therapy

15 Mechanism of Action of Atypical Antipsychotics

16 Efficacy of Antipsychotics in Patients With DRP

17 Safety of Antipsychotics in Patients With DRP

18 Rationale for SSRI Therapy in DRP

19 Efficacy and Safety of SSRIs

20 Rationale for Combining Acetylcholinesterase Inhibitors and Memantine in Treating DRP

21 Efficacy of AChEI + Memantine on DRP Posthoc Analysis of Pooled Data From 3 RCTs

22 Efficacy of AChEI + Memantine on DRP Posthoc Analysis of Pooled Data From 3 RCTs

23 Rational for the Use of Pimavanserin to Treat DRP

24 Phase 2 RDBPC Trial of the Efficacy and Safety of Pimavanserin in Patients With AD and Psychosis

25 Phase 2 RDBPC Trial of the Efficacy and Safety of Pimavanserin in Patients With AD Prespecified Subgroup Analysis in Patients With Severe Psychosis

26 Ongoing Clinical Studies for Psychosis in DPR

27 Conclusions

28 Abbreviations

29 Abbreviations (cont)

30 Abbreviations (cont)


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