1. Architecture, immunophenotype, and consequences of AITL
Architecture, immunophenotype, and consequences of AITL. (A) Lymph node effacement devoid of follicles with characteristic CXCL13+ T cells.
Architecture, immunophenotype, and consequences of AITL. (A) Lymph node effacement devoid of follicles with characteristic CXCL13+ T cells. (B) An illustration of the cellular components of the microenvironment and immunophenotype in AITL including HEVs, EBV+ B cells, and TFH. The B-cell activation leads to consequences commonly of AIHA and hypergammaglobulinemia (PGUS).
Matthew A. Lunning, and Julie M. Vose Blood 2017;129:
©2017 by American Society of Hematology