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1H-MR spectroscopy of medulloblastoma

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1 1H-MR spectroscopy of medulloblastoma
1H-MR spectroscopy of medulloblastoma. 1H spectra of a solid-appearing medulloblastoma (A) and of a medulloblastoma with necrotic/cystic areas (B) and corresponding T2-weighted transverse fast spin-echo MR image [repetition time (TR)/echo time (TE), 3500/85... 1H-MR spectroscopy of medulloblastoma. 1H spectra of a solid-appearing medulloblastoma (A) and of a medulloblastoma with necrotic/cystic areas (B) and corresponding T2-weighted transverse fast spin-echo MR image [repetition time (TR)/echo time (TE), 3500/85 ms; 256 × 192 matrix; 2 signals acquired; echo-train length of 16; acquisition time of 2 minutes 48 seconds] indicating the region of interest. Absolute quantitation included a correction for the different fraction of cystic tissue (6% versus 48%), and spectra are scaled to allow direct comparison of peak areas. A singlet at 3.78 ppm consistent with guanidinoacetate (Gau) is observed, and taurine (Tau) is detected as a complex signal intensity at ≈3.4 ppm. Note the different levels of Tau, creatine (Cr), and glutamate/glutamine (Glu/Gln) signal intensity in the spectra. Spectra also exhibit broad lipid and macromolecule resonances at 0.9 and 1.3 ppm. One peak of the lactate (Lac) doublet at 1.33 ppm is detected as a shoulder of the broad LipMM13 resonance. N-acetylaspartate (NAA) is depleted, and total choline (tCho) is prominent in all spectra of medulloblastoma. The insert in spectrum A shows the spectrum of Tau scaled to the size of the fitted Tau components. Shown are the unfiltered raw data (thin line) and the LCModel fit to the data (thick line). A. Panigrahy et al. AJNR Am J Neuroradiol 2006;27: ©2006 by American Society of Neuroradiology

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