1. Fig. 3. Strategy for the development of probiotics as prophylactic and therapeutic microbial agent. More stress should be laid on strain specificity and identification of effector molecules derived from probiotics in the assessment of preclinical efficacy of probiotics. Preclinical safety assessment should include studies in healthy and immunocompromised animals. Clinical community should develop standardized protocols to avoid heterogeneity in studies and allow pooling of data and generalization of results obtained. We recommend qualitative and quantitative assessments for the post-production aspects of probiotics before marketing, to ensure uniformity in marketed products. Future research should focus on these aspects to improvise the current methods to find a balance between safety and efficacy while maintaining quality of product delivered.
Fig. 3. Strategy for the development of probiotics as prophylactic and therapeutic microbial agent. More stress should be laid on strain specificity and identification of effector molecules derived from probiotics in the assessment of preclinical efficacy of probiotics. Preclinical safety assessment should include studies in healthy and immunocompromised…
Allergy Asthma Immunol Res Nov;10(6):