1. Monoclonal Ig deposition disease (MIDD) with diffuse and nodular glomerulosclerosis.
Monoclonal Ig deposition disease (MIDD) with diffuse and nodular glomerulosclerosis. There is prominent diffuse mesangial expansion by periodic acid-Schiff–positive matrix that focally forms nodules. Although the glomerulus shows atrophy with some capillary collapse, the resemblance to diabetic glomerulosclerosis is obvious. There were monoclonal deposits of κ Ig light chains in the glomerular and tubular basement membranes, and there were typical punctuate deposits in the basement membranes seen by electron microscopy. Periodic acid-Schiff stain. Courtesy of Jean L. Olson, University of California San Francisco, School of Medicine, San Francisco, California.
Stephen M. Korbet, and Melvin M. Schwartz JASN 2006;17:
©2006 by American Society of Nephrology