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Myosin light chain kinase mediates eosinophil chemotaxis in a mitogen-activated protein kinase–dependent manner  Tetsuya Adachi, MDa, Susan Stafford,

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Presentation on theme: "Myosin light chain kinase mediates eosinophil chemotaxis in a mitogen-activated protein kinase–dependent manner  Tetsuya Adachi, MDa, Susan Stafford,"— Presentation transcript:

1 Myosin light chain kinase mediates eosinophil chemotaxis in a mitogen-activated protein kinase–dependent manner  Tetsuya Adachi, MDa, Susan Stafford, BSb, Hiroyuki Kayaba, MDa, Junichi Chihara, MD, PhDa, Rafeul Alam, MD, PhDb  Journal of Allergy and Clinical Immunology  Volume 111, Issue 1, Pages (January 2003) DOI: /mai Copyright © 2003 Mosby, Inc. Terms and Conditions

2 Fig. 1 A, Kinase activity of MLCK in eotaxin-stimulated eosinophils. Data are expressed as means ± SD (n = 3). *P < .05 versus without inhibitor; **P < .05 versus control (ANOVA). B, Effect of PD98059 and SB on eotaxin-induced phosphorylation of MLCK in eosinophils. The upper blot was representative of 3 independent experiments. The lower panel represents the data from the densitometric analysis expressed as means ± SD (n = 3). *P < .05 versus eotaxin stimulation (ANOVA). Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

3 Fig. 2 A, Phosphorylation of MLC in eosinophils. The upper blot was representative of 3 independent experiments. The lower panel represents the data from the densitometric analysis expressed as means ± SD (n = 3). **P < .05 versus no eotaxin. B, Effect of ML-7 on eotaxin-induced eosinophil chemotaxis. Data are expressed as means ± SD (n = 3). *P < .05 versus without inhibitor (ANOVA). Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

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