1. Fecal calprotectin and alpha-1 antitrypsin predict severity and response to corticosteroids in gastrointestinal graft-versus-host disease
by Paula Rodriguez-Otero, Raphael Porcher, Régis Peffault de Latour, Margarita Contreras, Yoram Bouhnik, Aliénor Xhaard, Annalisa Andreoli, Patricia Ribaud, Nathalie Kapel, Anne Janin, Gérard Socié, and Marie Robin
Blood
Volume 119(24):
June 14, 2012
©2012 by American Society of Hematology

2. Relationship between fecal markers and diagnosis of GI-GVHD.
Relationship between fecal markers and diagnosis of GI-GVHD. The panels show concentration of calprotectin (A), elasatse (B), and alpha1-antitrypsin (C) by clinic in this order: patients with no GI symptoms, patients with diarrhea not related to GVHD, patients with stage 1 GI-GVHD, patients with stage 2 GI-GVHD, and patients with stage 3 GI-GVHD. Box and whisker plots display the median, 25th, and 75th percentile of the distribution (box), and whiskers extend to the most extreme data point which is no more than 1.5 times the interquartile range from the box.
Paula Rodriguez-Otero et al. Blood 2012;119:
©2012 by American Society of Hematology

3. Cumulative incidence of CR in patients with GI-GVHD.
Cumulative incidence of CR in patients with GI-GVHD. The curve is represented in gray with a 95% CI. The curve on the top represents the cumulative incidence of response and the down curve represents the competing risk (death).
Paula Rodriguez-Otero et al. Blood 2012;119:
©2012 by American Society of Hematology

4. OS of the 51 patients with GI-GVHD.
OS of the 51 patients with GI-GVHD. (A) The OS rate by GI-GVHD stage. (B) The OS rate by WHO performance status staging. (C) The OS rate by the concentration of calprotectin. (D) The OS rate by the concentration of α1-AT concentration. (E) The survival rate by the concentration of albumin. (F) The survival rate by GI-GVHD stage and calprotectin levels with 3 groups: (1) stage 1 and stage 2 with a normal concentration of calprotectin; (2) stage 2 with a high concentration of calprotectin and stage 3 with a normal concentration of calprotectin; (3) stage 3 with a high concentration of calprotectin.
Paula Rodriguez-Otero et al. Blood 2012;119:
©2012 by American Society of Hematology