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Identification and characterization of activated integrin pathway module by signal transduction representation (A) and unsupervised hierarchical clustering.

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Presentation on theme: "Identification and characterization of activated integrin pathway module by signal transduction representation (A) and unsupervised hierarchical clustering."— Presentation transcript:

1 Identification and characterization of activated integrin pathway module by signal transduction representation (A) and unsupervised hierarchical clustering (B). Identification and characterization of activated integrin pathway module by signal transduction representation (A) and unsupervised hierarchical clustering (B). For the pathway representation, the inhibitory phosphorylations considered in the analysis are shown in red and the activating phosphorylations in green. For the unsupervised hierarchical clustering, the complete panel of NCI-60 is shown (vertical axis). Specific endpoint relative intensity values have been used to create the heatmap. After overall score calculation, we highlighted the cell lines with the top 10 pathway scores (red), and the cell lines with the lowest 10 pathway activation scores (green). Giulia Federici et al. Mol Cancer Res 2013;11: ©2013 by American Association for Cancer Research

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