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Molecular Chaperones in Cellular Protein Folding: The Birth of a Field

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Presentation on theme: "Molecular Chaperones in Cellular Protein Folding: The Birth of a Field"— Presentation transcript:

1 Molecular Chaperones in Cellular Protein Folding: The Birth of a Field
Arthur L. Horwich  Cell  Volume 157, Issue 2, Pages (April 2014) DOI: /j.cell Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 Evidence of Protein Misfolding In Vivo: Formation of Inclusion Bodies Transmission electron micrograph showing formation of inclusion bodies (arrowed) in E.coli expressing a trp-proinsulin fusion protein (from Williams et al., 1982). Cell  , DOI: ( /j.cell ) Copyright © 2014 Elsevier Inc. Terms and Conditions

3 Figure 2 A Transcriptional Response to Heat Stress
Drosophila busckii salivary gland chromosome spreads, showing “puffing” of two regions following temperature shift of larvae from 25°C (top) to 30°C for 30 min (bottom) (from Ritossa, 1962). Cell  , DOI: ( /j.cell ) Copyright © 2014 Elsevier Inc. Terms and Conditions


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