1. Moving Toward the Ground State
Ishan Kumar, Natalia Ivanova 
Cell Stem Cell 
Volume 17, Issue 4, Pages (October 2015)
DOI: /j.stem
Copyright © 2015 Elsevier Inc. Terms and Conditions

2. Figure 1 Putative Mechanism of 2i-Mediated Reprogramming
Upon transfer in 2i media, inhibition of the Mek-Erk pathway downregulates Egr1/2, while inhibition of Gsk3β activates canonical Wnt signaling through stabilization of Tcf/β-Catenin nuclear complexes. Differential expression of these factors leads to a rewiring of the enhancer network through differential recruitment of the core pluripotency factors Oct4, Nanog, and Sox2. Subsequently, enhancer rewiring leads to resetting of the transcriptome, epigenome, metabolome, and cell cycle.
Cell Stem Cell  , DOI: ( /j.stem )
Copyright © 2015 Elsevier Inc. Terms and Conditions