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AMG 176 exhibits robust single-agent activity in vivo.

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Presentation on theme: "AMG 176 exhibits robust single-agent activity in vivo."— Presentation transcript:

1 AMG 176 exhibits robust single-agent activity in vivo.
AMG 176 exhibits robust single-agent activity in vivo. A, Time- and dose-dependent effects of AMG 176 treatment on apoptotic markers (activated BAK, cleaved caspase-3, and cleaved PARP) in established OPM-2 luc tumors as measured in MSD immunoassays. B, Effects of AMG 176 on established OPM-2 luc tumor xenografts when dosed daily or on a 2-day on, 5-day off schedule. C, Effects of AMG 176 on established OPM-2 luc tumor xenografts when dosed once weekly. D, Effects of AMG 176 on MOLM13 luc orthotopic tumor xenografts when dosed on a 2-day-on, 5-day-off schedule. Representative day 15 bioluminescence images are shown. For xenograft studies, mean tumor volume or whole-body luminescence (dorsal + ventral image) ± SEM (n = 10/group) are reported. ***, P < (RMANOVA with Dunnett post hoc). E, Flow cytometry assessment of B cells, monocytes, and neutrophils in peripheral blood and bone marrow of human MCL1 knock-in mice following administration of AMG hours after cycle 1 (day 3) and cycle 2 (day 10). *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < (one-way ANOVA with Dunnett post hoc). Sean Caenepeel et al. Cancer Discov 2018;8: ©2018 by American Association for Cancer Research

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