1. Turning Reciprocal Feedback Regulation into Combination Therapy
Timothy C. Thompson 
Cancer Cell 
Volume 19, Issue 6, Pages (June 2011)
DOI: /j.ccr
Copyright © 2011 Elsevier Inc. Terms and Conditions

2. Figure 1
Reciprocal Inhibition Feedback Links AR- and PTEN Loss/PI3K-AKT Signaling Pathways in Prostate Cancer
As reported in Carver et al. (2011) and Mulholland et al. (2011), reciprocal negative feedback underlies the oncogenic activities of PTEN loss/PI3K-AKT signaling (depicted as the area inside the dotted “corners”). Activation of PI3K-AKT leads to suppression/subversion of AR signaling through suppression of HER kinases; upregulation of EGR1 and c-JUN transcriptional coregulators; and upregulation of the Polycomb group protein EZH2. Reciprocal negative feedback is established, in part, through AR-stimulated, FKBP5-mediated activation of AKT phosphatase PHLPP. GFs, growth factors.
Cancer Cell  , DOI: ( /j.ccr )
Copyright © 2011 Elsevier Inc. Terms and Conditions