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Young at Heart Cell Volume 153, Issue 4, Pages (May 2013)

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1 Young at Heart Cell Volume 153, Issue 4, Pages 743-745 (May 2013)
Leslie A. Leinwand, Brooke C. Harrison  Cell  Volume 153, Issue 4, Pages (May 2013) DOI: /j.cell Copyright © 2013 Elsevier Inc. Terms and Conditions

2 Figure 1 Systemic GDF11 Reduces Age-Related Cardiac Hypertrophy
(Inset) Heterochronic parabiosis reverses age-related cardiac hypertrophy in mice. Old (O) mice display increased cardiac mass and cardiomyocyte cross-sectional area compared to young (Y) mice. Heart mass and myocyte cross-sectional area are reduced in old mice subjected to heterochronic parabiosis with young mice (YO). Circulating levels of GDF11, possibly from the spleen and other tissues, are reduced in old mice. Supplementing old mice with recombinant GDF11 reverses age-related cardiac hypertrophy and promotes beneficial patterns of gene expression. The effects of circulating GDF11 (and associated age-related changes) on pancreatic insulin production, skeletal muscle, adipose tissue, and other tissues are unknown. Cell  , DOI: ( /j.cell ) Copyright © 2013 Elsevier Inc. Terms and Conditions

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