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IF2 and structural homologues.
IF2 and structural homologues. (A) Schematic representation of the E. coli IF2 primary structure. The domain boundaries and the lengths of the three IF2 isoforms are indicated. Ribbon diagrams of the structures of the IF2N domain from E. coli (PDB entry 1ND9) and the IF2 homologue aIF5B from M. thermoautotrophicum (PDB entry 1G7T) are shown. The domains are indicated in different colors, and the E. coli domain nomenclature is used. (B) Sequence alignment of selected bacterial IF2 and archaeal and eukaryotic homologues. Only a small part of the N-terminal nonconserved region is shown. Abbreviations: tth; T. thermophilus, bst, B. stearothermophilus; eco, E. coli; mth, M. thermoautotrophicum; hsa, H. sapiens. Secondary-structure elements defined from the structure of aIF5B from M. thermoautotrophicum are indicated by cylinders for helical segments and arrows for segments in β-strand conformation. The domain boundaries are indicated by yellow arrows. Color codes are as in Fig. 7. Brian Søgaard Laursen et al. Microbiol. Mol. Biol. Rev. 2005; doi: /MMBR
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