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Fig. 5. SUS treatment reduces Aβ in a second cohort of AD mice.

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Presentation on theme: "Fig. 5. SUS treatment reduces Aβ in a second cohort of AD mice."— Presentation transcript:

1 Fig. 5. SUS treatment reduces Aβ in a second cohort of AD mice.
SUS treatment reduces Aβ in a second cohort of AD mice. (A) A second cohort of APP23 mice was analyzed by Western blot with the anti-Aβ antibody W0-2; gel and transfer conditions were optimized to reveal the monomer and trimer specifically. The monomer was efficiently captured by using two sandwiched membranes. (B) The blots showed significant reduction of the monomer (fivefold reduction) and trimer (twofold reduction) in the extracellular fraction (unpaired t tests, P < 0.05). (C) ELISA for Aβ42 in the guanidine-insoluble fraction revealed a twofold reduction in SUS-treated compared to sham-treated mice (unpaired t test, P < 0.008; n = 10 per group). Gerhard Leinenga and Jürgen Götz Sci Transl Med 2015;7:278ra33 Copyright © 2015, American Association for the Advancement of Science

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