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Fig. 2 NGS bisulfite sequencing assay of DNA methylation in esophageal biopsies.
NGS bisulfite sequencing assay of DNA methylation in esophageal biopsies. (A) CCNA1 locus methylation (mCCNA1) in esophageal neoplasia and control patients. N Sq, normal squamous biopsies; NDBE, nondysplastic BE; HGD, BE with high-grade dysplasia. Fraction of methylated reads in each sample is indicated on the y axis. P < for one-way analysis of variance (ANOVA) comparison and P < for post hoc Student-Newman-Keuls test of N Sq versus BE, HGD, and EAC. (B) VIM locus methylation (mVIM) in esophageal neoplasia and control patients. Fraction of methylated reads in each sample is indicated on the y axis. P < for one-way ANOVA comparison and P < for post hoc Student-Newman-Keuls test of N Sq versus BE, HGD, and EAC. Helen R. Moinova et al., Sci Transl Med 2018;10:eaao5848 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works
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