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Early Clinical Predictors of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome after Myeloablative Stem Cell Transplantation  Lindsey E.

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Presentation on theme: "Early Clinical Predictors of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome after Myeloablative Stem Cell Transplantation  Lindsey E."— Presentation transcript:

1 Early Clinical Predictors of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome after Myeloablative Stem Cell Transplantation  Lindsey E. Roeker, Haesook T. Kim, Brett Glotzbecker, Prashant Nageshwar, Sarah Nikiforow, John Koreth, Philippe Armand, Corey Cutler, Edwin P. Alyea, Joseph H. Antin, Paul G. Richardson, Robert J. Soiffer, Vincent T. Ho  Biology of Blood and Marrow Transplantation  Volume 25, Issue 1, Pages (January 2019) DOI: /j.bbmt Copyright © Terms and Conditions

2 Figure 1 Comparison of (A) OS, (B) PFS, (C) NRM, and (D) relapse rate of patients who were alive and relapse-free at day +30 with VOD/SOS (n = 168) with those without VOD/SOS (n = 1573). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © Terms and Conditions

3 Figure 2 (A) Comparison of change in creatinine from preconditioning baseline at each time point described as median percent change for VOD/SOS cases and control subjects. *P < (B) Tacrolimus trough levels (ng/mL) in the 7 days preceding VOD diagnosis as compared with days +11 to +18 of transplant for control subjects. *P < Each dot represents median value. (C) Sirolimus trough levels (ng/mL) in the 7 days preceding VOD diagnosis as compared with days +11 to +18 of transplant for control subjects. *P < Each dot represents median value. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © Terms and Conditions


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