1. Thrombophilic Variables Do Not Increase the Generation or Procoagulant Activity of Thrombin During Cardiopulmonary Bypass 
Peter Raivio, MD, Jari Petäjä, MD, PhD, Anne Kuitunen, MD, PhD, Riitta Lassila, MD, PhD 
The Annals of Thoracic Surgery 
Volume 85, Issue 2, Pages (February 2008)
DOI: /j.athoracsur
Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

2. Fig 1
Prothrombin fragment F1+2 (panel A), D-dimer (panel B), and soluble fibrin monomer complexes (panel C) during and after the operation were not different in patients with at least one thrombophilic factor (n = 44) versus patients without any thrombophilic factor (no thrombophilia) (n = 56) (repeated measures analysis of variance, p = 0.09, p = 0.08, and p = 0.60, respectively). Time points measured are preoperatively (A), 15 minutes of CPB(B), immediately before the release of the aortic clamp (C), 15 minutes after the release of the aortic clamp (D), 30 minutes (E) and 6 hours after protamine administration (F), and on the first (G) and fifth (H) postoperative days. The time scale reflects actual time between time points A and F. Time points G and H are not in scale. Values are presented as mean ± standard error of the mean.
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

3. Fig 2
Prothrombin fragment F1+2 levels during and after the operation were not different in patients with more than one thrombophilic factor (n = 11) versus others (n = 89) (panel A), in patients with low levels of the natural anticoagulants antithrombin, protein C, or protein S (n = 22) versus others (n = 78) (panel B), or in patients with APC resistance due to factor V Leiden (n = 3) versus those without factor V Leiden (n = 97) (panel C) (repeated measures analysis of variance, p = 0.09, p = 0.16, and p = 0.68, respectively). Time points measured are preoperatively (A), 15 minutes of CPB (B), immediately before the release of the aortic clamp (C), 15 minutes after the release of the aortic clamp (D), 30 minutes (E) and 6 hours after protamine administration (F), and on the first (G) and fifth (H) postoperative days. The time scale reflects actual time between time points A and F. Time points G and H are not in scale. Values are presented as mean ± standard error of the mean.
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions