1. BCH 471 Biochemistry of Blood
Nora Aljebrin
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Office: Building 5 , 3rd floor, 304

2. Course Outline Lecture no. Topics
1-2
Blood; Its function, physical properties and composition: blood cells, plasma, serum, anticoagulants, blood parameters: CBC, red cell indices; hematocrite; erythrocyte sedimentation rate and its significance. 3
Blood plasma; its normal composition and variation in disease states
4-7
Plasma proteins: types (albumin, α1, α2, β1, β2, γ-globulins and fibrinogen); functions, biosynthesis; abnormalities, variation in different diseases; liver diseases, kidney diseases; multiple myeloma.

3. Course Outline Lecture no. Topics 8-10 11 12 13-15 16-17
Platelets; Blood coagulation pathways and homeostasis; disorders of blood clotting. Vitamin K deficiency; hemophilia 11
White blood cells, types, and structure, function and abnormalities; leukemia and other neoplasia. 12
Erythrocytes: structure and composition; erythrocyte membrane and cytoskeleton; advantage and disadvantage of anucleated cells
13-15
Hemoglobin: structure and function allosteric protein. O2 binding and effect of different factors on oxygen binding: cooperative effect bohr's effect; biosynthesis of hemoglobin and its requirements; types of hemoglobin; variation in hemoglobin types during development (ontogeny)
16-17
Red cell metabolism; glycolysis, pentose phosphate pathway; importance of glutathione; G6PDH deficiency and other enzyme deficiency and other enzyme deficiencies affecting red cell metabolism

4. Course Outline Lecture no. Topics 18-20
Erythrocyte hemolysis; heme degradation and bilirubin formation: conjugation and excretion of bilirubin; Jaundice and its types
21-22
Anaemias: definition and types. Acquired and genetic anaemias; iron deficiency anaemia; aplastic anaemia; sickle cell anaemia; thalassaemias; G-6-PD deficiency; polycythaemia
23-24
Blood formation: erythropoiesis; requirements; erythropoietin regulation; disorders of blood formation 25
Blood groups and blood transfusion; ABO, Rh, and duffy blood groups

5. Course Assessment Mid 1 14 marks Mid 2 14 marks Homework 2 marks
Midterm Exam dates
Mid 1: 7/2/1441
Mid 2: 13/3/1441
Mid marks
Mid marks
Homework marks
Lab marks
Total marks
Final marks

6. References
Harpers illustrated biochemistry 25th edition. Robert K. Murray; Darly K. Granner; Victor W Rodwel
Principles of Biochemistry: Mammalian Biochemistry 7th edition. Emil L. Smith, Robert L.HILL, I Robert Lehman, Robert J. Lefkowitz, Philip Handler, Abraham White.
Basic Histology: Text and Atlas 11th edition. Luiz Carlos Juqueria, Jose Carneiro
Tietz Fundamentals of Clinical Chemistry Carl A. Burti, Edward R. Ashwood, David E. Bruns