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Fig. 1 B2 RNA directly inhibits transcription.

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1 Fig. 1 B2 RNA directly inhibits transcription.
B2 RNA directly inhibits transcription. In the absence of B2 RNA, a functional closed preinitiation complex (PIC) can assemble. (Top) This complex can melt the dsDNA duplex, forming an open preinitiation complex to promote transcription initiation. In contrast, B2 RNA directly binds to RNA Pol II in a nonfunctional closed complex. (Bottom) B2 RNA precludes Pol II from making functional DNA contacts and thereby prevents dsDNA melting and open complex formation. Yicheng Long et al. Sci Adv 2017;3:eaao2110 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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