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Liver disease predicts mortality in patients with X-linked immunodeficiency with hyper- IgM but can be prevented by early hematopoietic stem cell transplantation 

Published byAvis Vivian Peters Modified over 5 years ago

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Presentation on theme: "Liver disease predicts mortality in patients with X-linked immunodeficiency with hyper- IgM but can be prevented by early hematopoietic stem cell transplantation "— Presentation transcript:

1 Liver disease predicts mortality in patients with X-linked immunodeficiency with hyper- IgM but can be prevented by early hematopoietic stem cell transplantation  Vian Azzu, MD, PhD, Lucinda Kennard, MD, Beatriz Morillo-Gutierrez, MD, Mary Slatter, MD, J. David M. Edgar, MD, Dinakantha S. Kumararatne, MD, PhD, William J.H. Griffiths, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 141, Issue 1, Pages e7 (January 2018) DOI: /j.jaci Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Kaplan-Meier survival curves in patients with XHIM with or without liver disease. A, Time 0 is birth. B, Time 0 is diagnosis of XHIM. In both plots, the timings of HSCT are shown as dashed lines above the graph. C, Survival in patients post HSCT. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig E1 Biochemical liver function tests in patients with XHIM with or without liver disease. A, Alkaline phosphatase. B, Gamma glutemyltranspeptidase. C, Alanine transaminase. D, Bilirubin. E, Prothrombin time. P values of less than .05 are considered significant. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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