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The effect of blood pressure on cerebral outcome in a rat model of cerebral air embolism during cardiopulmonary bypass  Ma Qing, MD, Jae-Kwang Shim, MD,

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Presentation on theme: "The effect of blood pressure on cerebral outcome in a rat model of cerebral air embolism during cardiopulmonary bypass  Ma Qing, MD, Jae-Kwang Shim, MD,"— Presentation transcript:

1 The effect of blood pressure on cerebral outcome in a rat model of cerebral air embolism during cardiopulmonary bypass  Ma Qing, MD, Jae-Kwang Shim, MD, PhD, Hilary P. Grocott, MD, FRCPC, Huaxin Sheng, MD, Joseph P. Mathew, MD, G. Burkhard Mackensen, MD, PhD  The Journal of Thoracic and Cardiovascular Surgery  Volume 142, Issue 2, Pages (August 2011) DOI: /j.jtcvs Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Neurologic function was evaluated on PODs 3 and 7 using a protocol that included assays of general status, vertical screen climbing, balance beam, and sensory performance (total possible deficit points = 48, 0 = no deficit). Animals exposed to MAP of 80 mm Hg (HM) or 60 to 70 mm Hg (ST) during normothermic CPB combined with CAE demonstrated significantly lower neurologic score on both PODs 3 and 7 compared with those exposed to MAP of 50 mm Hg (LM). HM, High MAP; ST, standard MAP; LM, low MAP. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Histologic outcome 7 day after normothermic CPB combined with CAE was evaluated by cerebral infarction volume. No statistically significant differences were noted in respect to the different MAP management (80 mm Hg, 60–70 mm Hg, and 50 mm Hg in the HM, ST, and LM groups, respectively) during CPB. HM, High MAP; ST, standard MAP; LM, low MAP. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions


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