1. FEV1/FVC ratios for females in the National Health and Nutrition Examination Survey III study are plotted against their age.
FEV1/FVC ratios for females in the National Health and Nutrition Examination Survey III study are plotted against their age. The graph compares the fixed cutoff of 70% to the lower limit of the normal range (defined as the lowest percentile) for making a diagnosis of airway obstruction. Black circles represent subjects with normal values (true negative) by either method, and green circles represent subjects with abnormal ratios (true positive) by either method. Red circles show false positives, that is, subjects whose FEV1/FVC is < 0.70 but above the lowest 5th percentile. Blue circles represent younger subjects who are false negatives because their ratios are > 0.70 but below the lowest 5th percentile. Using the fixed cutoff introduces an age-related bias and may misclassify older subjects as having airway obstruction or younger patients as normal when their lung function is significantly below their lowest 5th percentile. The receiver operating characteristic curve is shown in the inset. Courtesy Philip H Quanjer.
Gregg L Ruppel Respir Care 2015;60:
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