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Intra-articular Nrdc gene silencing with siRNA attenuates CAIA

Published byLina Lundqvist Modified over 5 years ago

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Presentation on theme: "Intra-articular Nrdc gene silencing with siRNA attenuates CAIA"— Presentation transcript:

1 Intra-articular Nrdc gene silencing with siRNA attenuates CAIA
Intra-articular Nrdc gene silencing with siRNA attenuates CAIA. (A) Screening of siRNAs against NRDC in RAW264.7, WEHI 13 VAR and mouse embryonic fibroblasts (MEF). Intra-articular Nrdc gene silencing with siRNA attenuates CAIA. (A) Screening of siRNAs against NRDC in RAW264.7, WEHI 13 VAR and mouse embryonic fibroblasts (MEF). (B) Schedule of the induction of CAIA and intra-articular injection of siRNA. (C) Photographs of the hind paws 4 days after the induction of CAIA. Anti-NRDC siRNA was injected in the left ankle, while control siRNA was injected in the right ankle joints of BALB/c WT mice. (D) Ankle thickness was measured daily after the induction of CAIA (n=5 per treatment). *p<0.05, Welch’s t-test.  Takayuki Fujii et al. RMD Open 2017;3:e000436 Copyright © BMJ Publishing Group & EULAR. All rights reserved.

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