1. Loss of NQO1 expression inhibits invasion of NSCLC
Loss of NQO1 expression inhibits invasion of NSCLC. A, and C, three-dimensional tumor spheroid invasion assays were performed on A549 shNQO1, H292 shNQO1-B, and A549 and H292 shCtr-L cell lines as described in “Materials and Methods.” Shown are photomicrogr...
Loss of NQO1 expression inhibits invasion of NSCLC. A, and C, three-dimensional tumor spheroid invasion assays were performed on A549 shNQO1, H292 shNQO1-B, and A549 and H292 shCtr-L cell lines as described in “Materials and Methods.” Shown are photomicrographs of representative spheroids from each cell line at 0 and 72 hours. B and D, graphical presentation of the tumor spheroid invasion distance migrated by A549 shNQO1 and H292 shNQO1-B cells as compared with A549 and H292 shCtr-L cell lines. B, P values for A549 shNQO1 versus A549 shCtr-R (P < ). D, P values for H292 shNQO1 versus H292 shCtr-L (P < ).
Brian Madajewski et al. Mol Cancer Res 2016;14:14-25
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