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Comparison of PD-L1 mAbs in IHC across multiple tumor types.

Published byEustace Mason Modified over 5 years ago

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Presentation on theme: "Comparison of PD-L1 mAbs in IHC across multiple tumor types."— Presentation transcript:

1 Comparison of PD-L1 mAbs in IHC across multiple tumor types.
Comparison of PD-L1 mAbs in IHC across multiple tumor types. Representative photomicrographs of select tumors stained with PD-L1 antibodies, 9A11, 7G11, E1L3N, 015, and SP142 (brown coloration) in cHL, DLBCL, NPC, NSCLC (a representative adenocarcinoma), and RCC, as indicated. Representative of 50 to 300 cases for 9A11, 7G11, E1L3N, and 015, and 11 cases for SP142. Kathleen M. Mahoney et al. Cancer Immunol Res 2015;3: ©2015 by American Association for Cancer Research

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Fig. 2. GPC3 expression in normal and tumor tissues.

Fig. 2. GPC3 expression in normal and tumor tissues.
Representative multiplex immunofluorescence image of synovial sarcoma with increased PD-L1/PD-1/CD8 cell densities at the tumor-invasive margin demonstrating.

Representative multiplex immunofluorescence image of synovial sarcoma with increased PD-L1/PD-1/CD8 cell densities at the tumor-invasive margin demonstrating.
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Gr-1+ MDSC in tumor-bearing mice produce IL-6.
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Highly related T9 and T3 sarcoma cells show distinct tumor growth patterns but similar PD-L1 expression kinetics in vivo. Highly related T9 and T3 sarcoma.

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CPI-444 efficacy requires CD8+ T cells and is associated with increased CD73 expression. CPI-444 efficacy requires CD8+ T cells and is associated with.

CPI-444 efficacy requires CD8+ T cells and is associated with increased CD73 expression. CPI-444 efficacy requires CD8+ T cells and is associated with.
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