1. DYNLRB1, AIMP1, and NPIPA1 expression correlate with survival in neuroblastoma.
DYNLRB1, AIMP1, and NPIPA1 expression correlate with survival in neuroblastoma. Kaplan–Meier analysis of two datasets, one containing all stages of neuroblastoma and the other containing only MYCN-nonamplified neuroblastoma, reveals that low expression of DYNLRB1 correlates with poor overall and event-free survival compared with high expression (A and B; P = 8.40 × 10−3 and P = 4.49 × 10−3). High AIMP1 expression correlates with poor overall and event-free survival compared with low expression in both datasets (C and D; P = 5.62 × 10−4 and P = 3.16 × 10−4). Low expression of NPIPA1 correlates with poor event-free survival compared with high expression, but is only significant in the MYCN-nonamplified cohort (E and F; P = 2.10 × 10−3 and P = N.S.). FDRs are given for the identification of the high and low expression groups. Significance was assessed by the log-rank test.
Justin Chen et al. Cancer Discovery 2015;5:
©2015 by American Association for Cancer Research