1. FIGURE 1 WT CD2 TG CD25 CONTROL IL-2 CD3/CD28 CD3/CD28+IL-2 74.3 9.9
45.4 52
50.7
47.9 WT TG
CD2
84.1
9.1
85.4
10.6
42.2
56.1
41.5 56
CD25
FIGURE 1

2. FIGURE 2 WT TG Thymidine Uptake (cpm) IL-2 Control CD3/CD28
2000
4000
6000
8000
10000
12000
14000
16000
18000
20000
Control
CD3/CD28
IL-2
IL-2 + CD3/CD28 WT TG
Thymidine Uptake (cpm)
FIGURE 2

3. FIGURE 3 WT TG ** * Unstimulated Anti-CD3/CD28 IL-10 (ng/mL)
0,5 1
1,5 2
2,5
200
400
600
800
1000
1200 20 40 60 80
100
120 10 30 50 70
0,1
0,2
0,3
0,4
0,6 ** *
IL-10 (ng/mL)
IL-4 (pg/mL)
IL-13 (pg/mL)
IFN- (ng/mL)
IL-2 (ng/mL)
Unstimulated
Anti-CD3/CD28
FIGURE 3 WT TG

4. * FIGURE 4 IL-2 + anti-CD3/28 IL-2 anti-CD3/28 Unstimulated CD4+ CD8+10 20 30 40 50 60
anti-CD3/28
Unstimulated
CD4+
CD8+ 70
FIGURE 4
PERCENTAGE OF CELL NUMBER WT TG

5. FIGURE 5 WT TG WT TG T CD4 CD8 10 20 30 40 50 60 70 % CELL NUMBER * 8010 20 30 40 50 60 70
T CD CD8
% CELL NUMBER * 80
100
120
140
CELL NUMBER WT TG
WT TG
FIGURE 5