1. Batch variation of formulations from two products by two different genomic-scale techniques.
Batch variation of formulations from two products by two different genomic-scale techniques. (A) The relative abundance of each bacterium in a product as determined by k-mer analysis of metagenomic sequencing. The results are for two examples, products G and H, across three respective lots. (B) Analysis of the same samples with the custom-designed high-density GutProbe microarray platform (9). Each spot is a summarized probe set intensity (red shading, <8.5 absent; blue shading, ≥8.5 present) for a specific gene array from available whole genomes of human gut-associated species, including common probiotics. As has been shown previously, this genomic-scale genotyping is exquisitely sensitive for the determination of the identities and formulations of products, especially when they are assessed in pairwise comparisons.
Jennifer N. Patro et al. mSphere 2016; doi: /mSphere