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Study design. Study design. Patients who completed the 8-week induction study and achieved clinical response-100 (decrease in Crohn's disease activity.

Published bySonia Marcela Carvalho Modified over 5 years ago

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Presentation on theme: "Study design. Study design. Patients who completed the 8-week induction study and achieved clinical response-100 (decrease in Crohn's disease activity."— Presentation transcript:

1 Study design. Study design. Patients who completed the 8-week induction study and achieved clinical response-100 (decrease in Crohn's disease activity index (CDAI) score at week 8 of at least 100 points from baseline) and/or clinical remission (CDAI <150) and met eligibility criteria, were potentially eligible to enter the 26-week maintenance study. Patients were followed up for 4 weeks after completion or early withdrawal of the induction or maintenance study. *Patients were initially randomised (3:2:2:4) to receive placebo, tofacitinib 5, 10 or 15 mg twice daily. A protocol amendment was implemented to stop enrolment in the tofacitinib 15 mg twice daily dose group after 16 patients were enrolled. BID, twice daily. Julian Panés et al. Gut 2017;66: Copyright © BMJ Publishing Group Ltd & British Society of Gastroenterology. All rights reserved.

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