1. Environmental factors such as diet, inflammation, and stress influence microbial composition and cause microbial dysbiosis.
Environmental factors such as diet, inflammation, and stress influence microbial composition and cause microbial dysbiosis. Expansion of cancer-promoting bacteria with procarcinogenic activities (toxins, metabolites) promotes epithelial cell DNA damage, which, in conjunction with host responses (cytokines, DNA damaging products) from the underlining tissues, fosters dysplastic events and cancer progression. H2S, hydrogen sulfide; RNS, radical nitrogen species; ROS, radical oxygen species.
Christian Jobin Cancer Discovery 2013;3:
©2013 by American Association for Cancer Research