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Epidermal Growth Factor Receptor Gene Mutation and Computed Tomographic Findings in Peripheral Pulmonary Adenocarcinoma  Motoki Yano, MD, PhD, Hidefumi.

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Presentation on theme: "Epidermal Growth Factor Receptor Gene Mutation and Computed Tomographic Findings in Peripheral Pulmonary Adenocarcinoma  Motoki Yano, MD, PhD, Hidefumi."— Presentation transcript:

1 Epidermal Growth Factor Receptor Gene Mutation and Computed Tomographic Findings in Peripheral Pulmonary Adenocarcinoma  Motoki Yano, MD, PhD, Hidefumi Sasaki, MD, PhD, Yoshihiro Kobayashi, MD, PhD, Haruhiro Yukiue, MD, PhD, Hiroshi Haneda, MD, Eriko Suzuki, MD, Katsuhiko Endo, MD, PhD, Osamu Kawano, MD, Masaki Hara, MD, PhD, Yoshitaka Fujii, MD, PhD  Journal of Thoracic Oncology  Volume 1, Issue 5, Pages (June 2006) DOI: /S (15)31604-X Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Maximal diameter, GGO occupied ratio, and the presence of mutation. ○, wild-type EGFR gene. •, mutation of EGFR gene. In the shaded area with a GGO ratio of ≥50% with a tumor size <3 cm, patients with EGFR mutations were seen more frequently compared with patients in the dotted or the unmarked area with a GGO ratio of <50% with a tumor ≥3 cm in diameter. Journal of Thoracic Oncology 2006 1, DOI: ( /S (15)31604-X) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Maximal diameter, GGO occupied ratio, and the presence of mutation among women. ○, wild-type EGFR gene. •, mutation of EGFR gene. The highest frequency (10 of 12) of EGFR mutations as defined by a GGO ratio of ≥50% with a tumor size <3 cm was seen in the shaded area. Journal of Thoracic Oncology 2006 1, DOI: ( /S (15)31604-X) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Maximal diameter, GGO occupied ratio and the presence of mutation among men. ○, wild-type EGFR gene. •, mutation of EGFR gene. In the unmarked area with a tumor ≥4.0 cm, none had EGFR mutation. Journal of Thoracic Oncology 2006 1, DOI: ( /S (15)31604-X) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

5 FIGURE 4 Maximal diameter, GGO occupied ratio, and types of mutation. •, deletion type of mutation in exon 19. ○, L858R mutation. Most tumors of L858R mutation were within 3 cm in a maximal diameter. Journal of Thoracic Oncology 2006 1, DOI: ( /S (15)31604-X) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

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