Presentation is loading. Please wait.

Presentation is loading. Please wait.

High-Dose ϵ-Aminocaproic Acid Versus Aprotinin: Antifibrinolytic Efficacy in First-Time Coronary Operations  Balthasar Eberle, Eckhard Mayer, Gerhard.

Published byMaria Jasmin Schmitz Modified over 5 years ago

Similar presentations

Presentation on theme: "High-Dose ϵ-Aminocaproic Acid Versus Aprotinin: Antifibrinolytic Efficacy in First-Time Coronary Operations  Balthasar Eberle, Eckhard Mayer, Gerhard."— Presentation transcript:

1 High-Dose ϵ-Aminocaproic Acid Versus Aprotinin: Antifibrinolytic Efficacy in First-Time Coronary Operations  Balthasar Eberle, Eckhard Mayer, Gerhard Hafner, Jens Heinermann, Manfred Dahm, Winfried Prellwitz, Wolfgang Dick, Hellmut Oelert  The Annals of Thoracic Surgery  Volume 65, Issue 3, Pages (March 1998) DOI: /S (97)

2 Fig. 1 Thrombin-antithrombin complex levels increase until termination of cardiopulmonary bypass (CPB) in all patients. Thereafter, the thrombin-antithrombin complex remains elevated for 12 postoperative hours in untreated patients, more than in patients receiving aprotinin or ϵ-aminocaproic acid (ϵ-ACA) (∗p < 0.05 versus aprotinin or ϵ-aminocaproic acid). Box plot shows medians, interquartile ranges (boxes), and 10th/90th percentiles (whiskers). The Annals of Thoracic Surgery  , DOI: ( /S (97) )

3 Fig. 2 Perioperative profiles of fibrinogen-fibrin split products (A) and, specifically, d-dimers (B). Both aprotinin and ϵ-aminocaproic acid (ϵ-ACA) effectively suppress their appearance. Untreated patients show highly elevated levels of fibrinolytic products (∗p < versus active drugs). Data are means ± standard errors. The Annals of Thoracic Surgery  , DOI: ( /S (97) )

4 Fig. 3 Perioperative profile of antiplasmin-plasmin complex levels. Patients treated with ϵ-aminocaproic acid (ϵ-ACA) show a significant increase of about 12 hours (∗p < 0.02 versus control). Aprotinin is most effective in suppressing antiplasmin-plasmin complex generation (∗∗p < versus ϵ-aminocaproic acid). Data are means ± standard errors. The Annals of Thoracic Surgery  , DOI: ( /S (97) )

5 Fig. 4 Four-hourly (bars) and cumulative (lines) postoperative thoracic drainage in first-time coronary artery bypass patients treated with either aprotinin, ϵ-aminocaproic acid (ϵ-ACA), or untreated controls. Both antifibrinolytics are highly effective (∗∗p < versus control). For 4 hours after completion of drug infusion, aprotinin reduces drainage transiently more than ϵ-aminocaproic acid (∗p < 0.02 versus ϵ-aminocaproic acid or control). Cumulative 24-hour analysis is not sensitive enough to recognize this difference. Graph shows means ± standard errors. The Annals of Thoracic Surgery  , DOI: ( /S (97) )

Download ppt "High-Dose ϵ-Aminocaproic Acid Versus Aprotinin: Antifibrinolytic Efficacy in First-Time Coronary Operations  Balthasar Eberle, Eckhard Mayer, Gerhard."

Similar presentations

Time course of cranial ultrasound abnormalities after arterial switch operation in neonates  Matthias Sigler, MD, Jaime F Vazquez-Jimenez, MD, Ralph G.

Time course of cranial ultrasound abnormalities after arterial switch operation in neonates  Matthias Sigler, MD, Jaime F Vazquez-Jimenez, MD, Ralph G.
Elevated Hemoglobin A1c Is Associated With Lower Socioeconomic Position and Increased Postoperative Infections and Longer Hospital Stay After Cardiac.

Elevated Hemoglobin A1c Is Associated With Lower Socioeconomic Position and Increased Postoperative Infections and Longer Hospital Stay After Cardiac.
Does Platelet Reactivity Predict Bleeding in Patients Needing Urgent Coronary Artery Bypass Grafting During Dual Antiplatelet Therapy?  Elisabeth Mahla,

Does Platelet Reactivity Predict Bleeding in Patients Needing Urgent Coronary Artery Bypass Grafting During Dual Antiplatelet Therapy?  Elisabeth Mahla,
Leena Khaitan, MD, Francis P Sutter, Scott M Goldman, MD 

Leena Khaitan, MD, Francis P Sutter, Scott M Goldman, MD 
Elevated Hemoglobin A1c Is Associated With Lower Socioeconomic Position and Increased Postoperative Infections and Longer Hospital Stay After Cardiac.

Elevated Hemoglobin A1c Is Associated With Lower Socioeconomic Position and Increased Postoperative Infections and Longer Hospital Stay After Cardiac.
Reduction of the Inflammatory Response in Patients Undergoing Minimally Invasive Coronary Artery Bypass Grafting  Y.John Gu, Massimo A Mariani, Willem.

Reduction of the Inflammatory Response in Patients Undergoing Minimally Invasive Coronary Artery Bypass Grafting  Y.John Gu, Massimo A Mariani, Willem.
John Parker Gott, MD, William A Cooper, MD, Frank E Schmidt, MD, W

John Parker Gott, MD, William A Cooper, MD, Frank E Schmidt, MD, W
Attenuation of Changes in Leukocyte Surface Markers and Complement Activation With Heparin-Coated Cardiopulmonary Bypass  Oddvar Moen, MD, Kolbjørn Høgåsen,

Attenuation of Changes in Leukocyte Surface Markers and Complement Activation With Heparin-Coated Cardiopulmonary Bypass  Oddvar Moen, MD, Kolbjørn Høgåsen,
Improvement of tricuspid regurgitation after pulmonary thromboendarterectomy  Thomas Menzel, MD, Thorsten Kramm, MD, Stephan Wagner, MD, Susanne Mohr-Kahaly,

Improvement of tricuspid regurgitation after pulmonary thromboendarterectomy  Thomas Menzel, MD, Thorsten Kramm, MD, Stephan Wagner, MD, Susanne Mohr-Kahaly,
Serum S100B and hypothermic circulatory arrest in adults

Serum S100B and hypothermic circulatory arrest in adults
Aprotinin Shows Both Hemostatic and Antithrombotic Effects During Off-Pump Coronary Artery Bypass Grafting  Robert S. Poston, MD, Charles White, MD, Junyan.

Aprotinin Shows Both Hemostatic and Antithrombotic Effects During Off-Pump Coronary Artery Bypass Grafting  Robert S. Poston, MD, Charles White, MD, Junyan.
Rewarming Rate During Cardiopulmonary Bypass Is Associated With Release of Glial Fibrillary Acidic Protein  Daijiro Hori, MD, Allen D. Everett, MD, Jennifer.

Rewarming Rate During Cardiopulmonary Bypass Is Associated With Release of Glial Fibrillary Acidic Protein  Daijiro Hori, MD, Allen D. Everett, MD, Jennifer.
Alterations in coagulation after implantation of a pulsatile Novacor LVAD and the axial flow micromed DeBakey LVAD  Andreas Koster, MD, Matthias Loebe,

Alterations in coagulation after implantation of a pulsatile Novacor LVAD and the axial flow micromed DeBakey LVAD  Andreas Koster, MD, Matthias Loebe,
Prospective, Randomized, Double-Blind Study of High-Dose Aprotinin in Pediatric Cardiac Operations  Michael J Davies, FRCS, Alison Allen, BScHons, Henry.

Prospective, Randomized, Double-Blind Study of High-Dose Aprotinin in Pediatric Cardiac Operations  Michael J Davies, FRCS, Alison Allen, BScHons, Henry.
James L Zellner, MD, Scott B Kribbs, BS, B

James L Zellner, MD, Scott B Kribbs, BS, B
Bashir M Matata, PhD, Andrzej W Sosnowski, MD, Manuel Galiñanes 

Bashir M Matata, PhD, Andrzej W Sosnowski, MD, Manuel Galiñanes 
Aprotinin and Dipyridamole for the Safe Reduction of Postoperative Blood Loss  Gideon Cohen, Joan Ivanov, Richard D Weisel, Vivek Rao, Molly K Mohabeer,

Aprotinin and Dipyridamole for the Safe Reduction of Postoperative Blood Loss  Gideon Cohen, Joan Ivanov, Richard D Weisel, Vivek Rao, Molly K Mohabeer,
Coronary artery operation in patients after breast cancer therapy

Coronary artery operation in patients after breast cancer therapy
Jens C Rückert, MD, Michael Walter, MD, Joachim M Müller, MD 

Jens C Rückert, MD, Michael Walter, MD, Joachim M Müller, MD 
Coagulofibrinolysis during heparin-coated cardiopulmonary bypass with reduced heparinization  Hiroshi Kumano, MD, PhD, Shigefumi Suehiro, MD, PhD, Koji.

Coagulofibrinolysis during heparin-coated cardiopulmonary bypass with reduced heparinization  Hiroshi Kumano, MD, PhD, Shigefumi Suehiro, MD, PhD, Koji.

Similar presentations

Ads by Google